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- Title
右美托咪定对高海拔地区全麻手术患者术后呼吸的影响.
- Authors
熊青青; 罗晓东; 付步芳; 钟家依; 和国莲
- Abstract
Objective To observe the effect of dexmedetomidine on respiration in postoperative patients undergone general anesthesia at high altitude areas. Methods 60 patients who received laparoscopic cholecystectomy under tracheal general anesthesia, and all the patients had been living in high altitude area (altitude: 2000 m~3 000 m) for at least one year. The patients were randomly assigned into two groups. The dexmedetomidine group received a 10-minute- infusion of dexmedetomidine 0.6 μg/kg, while the control group was given a volumematched normal saline in same dose. After operation, the tracheal tube was removed and then oxygen 3 L/min was given. A rapid arterial blood gas examination was performed one hour after operation. At the time points of 1 hour, 3 hours, 6 hours and 12 hours after operation, we examined the blood oxygen saturation and the respiratory rate, and recorded the number of patients with hypoxemia in both groups (Hypoxemia was considered to be present when blood oxygen saturation was ≤ 85%). Results The oxygen partial pressure at each postoperative point in both groups was higher than that before surgery (P < 0.05), and there was no statistically significant difference in oxygen partial pressure at each postoperative point in the two groups (P > 0.05). Oxygen saturation at each time point after operation in both groups was higher than that before operation (P < 0.05), and oxygen saturation at 3 h after operation in the dexmedetomidine group was lower than that in the control group (P < 0.05). The respiration rate of the dexmedetomidine group at 1 h, 3 h and 12 h after operation was lower than that of the control group (P < 0.05). No oxygen saturation below 85% was found in both groups after operation. Conclusion The administration of dexmedetomidine to patients under tracheal general anesthesia at high altitude areas will reduce the number of breaths and blood oxygen saturation at some time points, but it will not reduce the partial pressure of oxygen at 1 min after surgery, and will not cause postoperative hypoxemia.
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2020, Vol 41, Issue 12, p85
- ISSN
2095-610X
- Publication type
Article
- DOI
10.12259/j.issn.2095-610X.S20201224