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- Title
Change and Significience of Plasma S-100β Protein and NSE in Elderly Patients with Delirium after Hip Joint Replacement.
- Authors
YANG Yun-li; MA Wei-qing; ZHANG Cheng-hua; LI Zhi-gui; ZHAO Zhen
- Abstract
Objective To explore the chang and clinical significance of serum S-100 p protein and Neuron specific enolase (NES) concentratons in elderly patients with delirium after hip joint replacement. Methods One hundred eight ASA H ~ H patients of both sexes, aged 75 ~ 93 years, weighing 40~75kg underwent hip joint replacement under general anesthesia. PD was diagnosed by the Confusion Assessment Method (CAM) . The incidence of PD was recorded within 48 h after operation. The patients were divided into 2 groups according to the occurrence of PD within 48 h after operation: PD group and NPD group (n = 20 each) . Blood samples were taken at before anesthesia (T0) , durng their stay in PACU (T1), and at 24 and 48 h after operation (T2 , T3) for determination of serum S-100β protein and NSE concentratons. Results Compared with that at T0 and in NPD Group , the serum S-100β protein concentraton was significantly increased in PD group (p < 0.05) , While NSE did not. Conclusions Increase of the serum S-100β protein concentration can be used in predicting the development of PD in the elderly patients. The serum S-100 p protein concentraton can be used as a marker of PD patients.
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2014, Vol 35, Issue 4, p61
- ISSN
2095-610X
- Publication type
Article