We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Long-Term Follow-Up of Choroidal Neovascularization due to Angioid Streaks with pro re nata Intravitreal Anti-VEGF Treatment.
- Authors
Giacomelli, Giovanni; Finocchio, Lucia; Biagini, Ilaria; Sodi, andrea; Murro, Vittoria; Introini, Ugo; Varano, Monica; Bandello, Francesco; Menchini, Ugo
- Abstract
Purpose: To evaluate the long-term outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) drugs with a pro re nata (PRN) regimen for the treatment of choroidal neovascularization (CNV) secondary to angioid streaks (AS). Methods: This is a retrospective, multicenter, noncomparative case series of consecutive AS eyes affected by treatmentnaïve CNV. A complete ophthalmologic examination was performed every 30-45 days after the loading phase, including fluorescein angiography and/or optical coherence tomography. Results: In all, 52 eyes of 39 patients were treated with intravitreal bevacizumab and/or ranibizumab and followed up for a mean of 33.8 months. The best corrected visual acuity at baseline was 20/40, and it deteriorated by an average of 6.8 ETDRS letters per year ( p < 0.001). We performed an average of 5.1, 6.5, and 6.8 injections at the 1-, 2-, and 3-year follow-up, respectively. Conclusions: Intravitreal anti-VEGF drugs in a PRN regimen with close monitoring appear to slow the progression of CNV in AS, but they do not prevent the affected eyes from progressive visual loss.
- Subjects
CHOROID diseases; NEOVASCULARIZATION; VASCULAR endothelial growth factor antagonists; RANIBIZUMAB; BEVACIZUMAB; FOLLOW-up studies (Medicine); THERAPEUTICS
- Publication
Ophthalmologica, 2017, Vol 238, Issue 1/2, p44
- ISSN
0030-3755
- Publication type
Article
- DOI
10.1159/000477498