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- Title
Advanced Age as a Predictor of Survival and Weaning in Venoarterial Extracorporeal Oxygenation: A Retrospective Observational Study.
- Authors
Lee, WooSurng; Kim, YoHan; Choi, HyunHee; Kim, HyoungSoo; Lee, SunHee; Lee, HeeSung; Chee, HyunKeun; Kim, JunSeok; Hwang, JaeJoon; Lee, SongAm; Kim, YongHun; Cho, SeongJoon; Ryu, SeMin; Park, SungMin
- Abstract
Background. In most reports on ECMO treatment, advanced age is classified as a contraindication to VA ECMO. We attempted to investigate whether advanced age would be a main risk factor deciding VA ECMO application and performing VA ECMO support. We determined whether advanced age should be regarded as an absolute or relative contraindication to VA ECMO and could affect weaning and survival rates of VA ECMO patients. Methods. VA ECMO was performed on 135 adult patients with primary cardiogenic shock between January 2010 and December 2014. Successful weaning was defined as weaning from ECMO followed by survival for more than 48 hours. Results. Among the 135 patients, 35 survived and were discharged uneventfully, and the remaining 100 did not survive. There were significant differences in survival between age groups, and older age showed a lower survival rate with statistical significance (P = .01). By multivariate logistic regression analysis, age was not significantly associated with in-hospital mortality (P = .83) and was not significantly associated with VA ECMO weaning (P = .11). Conclusions. Advanced age is an undeniable risk factor for VA ECMO; however, patients of advanced age should not be excluded from the chance of recovery after VA ECMO treatment.
- Subjects
HEPARIN; ARTERIES; VEINS; AGE distribution; CARDIAC arrest; CHI-squared test; CONFIDENCE intervals; ETHICS; EXTRACORPOREAL membrane oxygenation; LIFE support systems in critical care; MEDICAL care; MULTIVARIATE analysis; PATIENTS; STATURE; SURVIVAL; T-test (Statistics); BODY mass index; PROPORTIONAL hazards models; RETROSPECTIVE studies; RECEIVER operating characteristic curves; DATA analysis software; KAPLAN-Meier estimator; MANN Whitney U Test; ANATOMY
- Publication
BioMed Research International, 2017, Vol 2017, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2017/3505784