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- Title
Heterogenous antibody and T‐cell responses to SARS‐CoV‐2 mRNA vaccines among immunocompromised young people.
- Authors
Lu, Liangjian; Chan, Chang Yien; Chan‐Ng, Pauline P. L.; Than, Mya; Tan, Pamela S. Y.; Lim, Lee Kean; Teo, Sharon; Lau, Perry YW; Ng, Kar Hui; Ang, Elizabeth Y.; Karthik, Sivaramakrishnan Venkatesh; Aw, Marion M.; Tambyah, Paul A.; Yap, Hui Kim; Lee, Bee Wah
- Abstract
In a representative cohort of immunocompromised young people, we observed marked differences in humoral and cellular responses to a standard two-dose mRNA vaccination regime between disease categories. In conclusion, although immunocompromised young people display attenuated humoral and cellular responses to vaccination in general, there are marked differences in vaccine responses between disease subgroups, not completely explained by immunosuppression used. First, given the heterogeneity in vaccine responses, some patient groups who qualify for an additional primary vaccination dose, for example JIA patients, may not benefit significantly, resulting in suboptimal use of vaccines and vaccination capacity.
- Subjects
YOUNG adults; COVID-19 vaccines; IMMUNOGLOBULINS; T cells; ANTIBODY formation; MONONUCLEAR leukocytes
- Publication
Clinical & Translational Medicine, 2023, Vol 13, Issue 1, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1183