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- Title
Metabolic dysregulation in patients with premature ovarian insufficiency revealed by integrated transcriptomic, methylomic and metabolomic analyses.
- Authors
Lu, Cuiling; Qin, Caimeng; Fu, Zheng; Wang, Lina; Yi, Yanxiao; Xin, Mingwei; Zhen, Xiumei; Han, Chunsheng
- Abstract
Then, we profiled metabolites in the patients' sera and identified some metabolites with changed levels, including fumarate, arachidonate and acetoacetate, and the combination of hyodeoxycholic acid (HDCA) and acetoacetate may be used as one of potential biomarkers for POI. Premature ovarian insufficiency (POI) is a disorder of ovarian function, which occurs in approximately 3.7% of women younger than 40 years of age.1 The aetiologies of most cases were unknown and usually manifest as isolated organ senescence at early stage of diagnosis, only with long-term consequences of increased risk of metabolic syndrome or disease.2 We tried to explore the essence of POI from multiple dimensions. Out of the 13 validated DMets, 5 (acetoacetate, glutamate, C22:1, arachidonate and succinate) and 4 (HDCA, C22:0, homocitrulline [Hcit] and fumarate) were increased and decreased in the sera of POI patients, respectively.
- Subjects
PREMATURE ovarian failure; GLUTAMINE synthetase; METABOLOMICS; TRANSCRIPTOMES; GENE regulatory networks
- Publication
Clinical & Translational Medicine, 2022, Vol 12, Issue 10, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1006