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- Title
Inflammation in multiple sclerosis induces a specific reactive astrocyte state driving non‐cell‐autonomous neuronal damage.
- Authors
Matute‐Blanch, Clara; Brito, Verónica; Midaglia, Luciana; Villar, Luisa M; Garcia‐Diaz Barriga, Gerardo; Guzman de la Fuente, Alerie; Borrás, Eva; Fernández‐García, Sara; Calvo‐Barreiro, Laura; Miguez, Andrés; Costa‐Frossard, Lucienne; Pinteac, Rucsanda; Sabidó, Eduard; Alberch, Jordi; Fitzgerald, Denise C.; Montalban, Xavier; Comabella, Manuel
- Abstract
Dear Editor An in-depth understanding of the neurodegenerative component of multiple sclerosis (MS) is crucial for the design of therapeutic approaches that may stop disease progression. Inflammation in multiple sclerosis induces a specific reactive astrocyte state driving non-cell-autonomous neuronal damage (A) Flowchart depicting CSF collection from a cohort of MS patients with high inflammatory activity (MS-High; N = 4), followed by exposure of astrocytes to the CSF in vitro, secretome collection and co-culture with neurons. (A, B) Liquid chromatography/mass spectrometry analysis of CSF from MS patients with inflammatory activity (MS-High; N = 9), low inflammatory activity (MS-Low; N = 9) and non-inflammatory neurological controls (NINC; N = 9).
- Subjects
ASTROCYTES; MULTIPLE sclerosis; CEREBROSPINAL fluid examination; MITOGEN-activated protein kinases; INFLAMMATION
- Publication
Clinical & Translational Medicine, 2022, Vol 12, Issue 5, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.837