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- Title
Immunogenomic alterations of head and neck squamous cell carcinomas stratified by smoking status.
- Authors
Huang, Yixuan; Zhang, Peng
- Abstract
Abbreviations FDR false discovery rate GSEA gene-set enrichment analysis HNSCC head and neck squamous cell carcinoma HR hazard ratio IFIT interferon-induced protein with tetratricopeptide repeats OS overall survival TCGA The Cancer Genome Atlas TMB tumor mutation burden TME tumor microenvironment UMAP uniform manifold approximation and projection Accumulating evidence revealed that the immunologic sequelae of smoking may contribute to the progression and treatment resistance of various cancer types, including lung cancer and head and neck squamous cell carcinoma (HNSCC).1,2 Moreover, according to the statistics on clinical outcome of immune checkpoint therapy, only a minority (10%-15%) of HNSCC patients could benefit from immunotherapy, and the smoking patients with HNSCC tend to have a lower response rate.3,4 Numerous studies were aimed to access the single nucleotide variation and copy number aberration that was associated with tobacco use of HNSCC, but lacked immunogenomic investigation.5 Thus, there is urgently needed to examine the correlation between smoking and immunogenomic changes in HNSCC. Gene ontology enrichment analysis of up-regulated genes showed many cell-cell signaling modules were significantly enriched in the smoking HNSCC samples (Figure 1G). Thus, the smoking HNSCC samples exhibited significantly reduced interferon pathway activities and altered interferon-producing immune phenotypes.
- Subjects
NECK; SQUAMOUS cell carcinoma; SMOKING; TUMOR-infiltrating immune cells; SINGLE nucleotide polymorphisms
- Publication
Clinical & Translational Medicine, 2021, Vol 11, Issue 11, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.599