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- Title
A case of malignant haemangioendothelioma treated with recombinant interleukin-2.
- Authors
Ansai, S.; Goto, K.; Aoki, T.; Hozumi, Y.; Aso, K.
- Abstract
A case of malignant haemangioendothelioma of the scalp in an 82-year-old female treated with intralesional, intraarterial and intravenous recombinant interleukin-2 (rIL-2) is reported. The scalp lesions disappeared after injection of 35 350 000 Japan reference units of rIL-2 and excision of the residual tumour. Immunohistochemical characterization of the cells infiltrating the lesion after rIL-2 administration revealed 30-40% CD4+ and CD8+ T lymphocytes, 20-30% macrophages and 5-10% natural killer cells. These findings are similar to those in other human cancers. Almost all of the cells in the intersticies of the lesion after rIL-2 injection expressed leucocyte function-associated antigen-1, and some of the tumour cells and the infiltrating cells around them expressed intercellular adhesion molecule-1. HLA-DR-positive cells markedly increased in number after rIL-2 administration. This report suggests that rIL-2 administration is the most effective therapy for malignant haemangioendothelioma.
- Subjects
ANGIOSARCOMA; BLOOD-vessel tumors; SARCOMA; DISEASES in older women
- Publication
Clinical & Experimental Dermatology, 1993, Vol 18, Issue 5, p470
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/j.1365-2230.1993.tb02255.x