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- Title
Serum oxidative stress biomarkers in congenital cataract patients.
- Authors
Saygili, E. İ; Aksoy, Ş. N.; Gürler, B.; Ceylan, N.; Erel, O.
- Abstract
Oxidative stress due to free radicals is related to the pathogenesis of many chronic disorders including cancer, inflammation and neurological diseases. Oxidative stress due to aging and light exposure is also considered to be associated with age-related macular degeneration and cataract. The ocular surface is chronically exposed to oxidative stress by means of ultraviolet light, oxygen in the air and changes in oxygen pressure due to blinking. The accurate assessment of oxidative stress in biological systems is a problem for all investigators working on the role of free radical damage in disease states. The concept of a single test that might reflect total antioxidant capacity (TAC) is an attractive one, and in this issue Erel et al describe one such test. The ratio of TOS to TAC yields the oxidative stress index (OSI), an indicator of the degree of oxidative stress. OSI (arbitrary unit); TOS (mmol H2O2 equiv. /L)/ TAC (mmol Trolox Equiv. /L). To our knowledge, no investigation has been conducted to demonstrate the importance of TAC, TOS and OSI levels Childs with congenital cataract. Blood samples were obtained from healthy subjects (n = 20) and congenital cataract childs (n = 20). Venous blood samples were obtained and collected into tubes and serum was separated from cells by centrifugation at 1500 x g for 10 min. Serum samples were run immediately or stored at -80°C. The congenital cataract patients' mean age was 4 (range, 1 to 7 years), the control group's mean age was 3 (range 2 to 7 years). TAC and TOS levels lower in congenital cataract subjects than in the control subjects (P >0.05). OSI level was significantly higher in congenital cataract subjects than in the control subjects (P<0.001).
- Publication
Cell Membranes & Free Radical Research, 2008, Vol 1, Issue 1, p37
- ISSN
1308-416X
- Publication type
Article