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- Title
The Long Elusive IgM Fc Receptor, FcμR.
- Authors
Kubagawa, Hiromi; Oka, Satoshi; Kubagawa, Yoshiki; Torii, Ikuko; Takayama, Eiji; Kang, Dong-Won; Jones, Dewitt; Nishida, Naonori; Miyawaki, Toshio; Bertoli, Luigi; Sanders, Sheila; Honjo, Kazuhito
- Abstract
IgM exists as both a monomer on the surface of B cells and a pentamer secreted by plasma cells. Both pre-immune 'natural' and antigen-induced 'immune' IgM antibodies are important for protective immunity and for immune regulation of autoimmune processes by recognizing pathogens and self-antigens. Effector proteins interacting with the Fc portion of IgM, such as complement and complement receptors, have thus far been proposed but fail to fully account for the IgM-mediated protection and regulation. A major reason for this deficit in our understanding of IgM function seems to be lack of data on a long elusive Fc receptor for IgM (FcμR). We have recently identified a bona fide FcμR in both humans and mice. In this article we briefly review what we have learned so far about FcμR.
- Subjects
IMMUNOGLOBULIN M; FC receptors; MONOMERS; B cells; PLASMA cells; AUTOIMMUNE disease treatment; PATHOGENIC microorganisms
- Publication
Journal of Clinical Immunology, 2014, Vol 34, p35
- ISSN
0271-9142
- Publication type
Article
- DOI
10.1007/s10875-014-0022-7