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Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias.
Published in:
2020
By:
- Pabel, Steffen;
- Mustroph, Julian;
- Stehle, Thea;
- Lebek, Simon;
- Dybkova, Nataliya;
- Keyser, Andreas;
- Rupprecht, Leopold;
- Wagner, Stefan;
- Neef, Stefan;
- Maier, Lars S;
- Sossalla, Samuel
Publication type:
journal article
Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure.
Published in:
2016
By:
- Fischer, Thomas H.;
- Herting, Jonas;
- Eiringhaus, Jörg;
- Pabel, Steffen;
- Hartmann, Nico H.;
- Ellenberger, David;
- Friedrich, Martin;
- Renner, André;
- Gummert, Jan;
- Maier, Lars S.;
- Zabel, Markus;
- Hasenfuss, Gerd;
- Sossalla, Samuel
Publication type:
journal article
Structural Analysis of Mitochondrial Dynamics—From Cardiomyocytes to Osteoblasts: A Critical Review.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 9, p. 4571, doi. 10.3390/ijms23094571
By:
- Mendelsohn, Daniel H.;
- Schnabel, Katja;
- Mamilos, Andreas;
- Sossalla, Samuel;
- Pabel, Steffen;
- Duerr, Georg Daniel;
- Keller, Karsten;
- Schmitt, Volker H.;
- Barsch, Friedrich;
- Walter, Nike;
- Wong, Ronald Man Yeung;
- El Khassawna, Thaqif;
- Niedermair, Tanja;
- Alt, Volker;
- Rupp, Markus;
- Brochhausen, Christoph
Publication type:
Article
Detrimental proarrhythmogenic interaction of Ca2+/calmodulin-dependent protein kinase II and NaV1.8 in heart failure.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26690-1
By:
- Bengel, Philipp;
- Dybkova, Nataliya;
- Tirilomis, Petros;
- Ahmad, Shakil;
- Hartmann, Nico;
- A. Mohamed, Belal;
- Krekeler, Miriam Celine;
- Maurer, Wiebke;
- Pabel, Steffen;
- Trum, Maximilian;
- Mustroph, Julian;
- Gummert, Jan;
- Milting, Hendrik;
- Wagner, Stefan;
- Ljubojevic-Holzer, Senka;
- Toischer, Karl;
- Maier, Lars S.;
- Hasenfuss, Gerd;
- Streckfuss-Bömeke, Katrin;
- Sossalla, Samuel
Publication type:
Article
Empagliflozin enhances human and murine cardiomyocyte glucose uptake by increased expression of GLUT1.
Published in:
Diabetologia, 2019, v. 62, n. 4, p. 726, doi. 10.1007/s00125-019-4819-z
By:
- Mustroph, Julian;
- Lücht, Charlotte M.;
- Wagemann, Olivia;
- Sowa, Thomas;
- Hammer, Karin P.;
- Sag, Can M.;
- Tarnowski, Daniel;
- Holzamer, Andreas;
- Pabel, Steffen;
- Beuthner, Bo Eric;
- Sossalla, Samuel;
- Maier, Lars S.;
- Wagner, Stefan
Publication type:
Article
Atrial fibrillation and heart failure: novel insights into the chicken and egg dilemma.
Published in:
European Heart Journal, 2022, v. 43, n. 36, p. 3376, doi. 10.1093/eurheartj/ehac257
By:
- Pabel, Steffen;
- Sossalla, Samuel
Publication type:
Article
Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart.
Published in:
Cardiovascular Research, 2018, v. 114, n. 13, p. 1728, doi. 10.1093/cvr/cvy152
By:
- Dybkova, Nataliya;
- Ahmad, Shakil;
- Pabel, Steffen;
- Tirilomis, Petros;
- Hartmann, Nico;
- Fischer, Thomas H;
- Bengel, Philipp;
- Tirilomis, Theodoros;
- Ljubojevic, Senka;
- Renner, André
Publication type:
Article
Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation.
Published in:
Cardiovascular Research, 2021, v. 117, n. 2, p. 495, doi. 10.1093/cvr/cvaa123
By:
- Kolijn, Detmar;
- Pabel, Steffen;
- Tian, Yanna;
- Lódi, Mária;
- Herwig, Melissa;
- Carrizzo, Albino;
- Zhazykbayeva, Saltanat;
- Kovács, Árpád;
- Fülöp, Gábor Á;
- Falcão-Pires, Inês;
- Reusch, Peter H;
- Linthout, Sophie Van;
- Papp, Zoltán;
- Heerebeek, Loek van;
- Vecchione, Carmine;
- Maier, Lars S;
- Ciccarelli, Michele;
- Tschöpe, Carsten;
- Mügge, Andreas;
- Bagi, Zsolt
Publication type:
Article
A mechanistic rationale for the investigation of sodium–glucose co‐transporter 2 inhibitors in heart failure with preserved ejection fraction. Letter regarding the article 'Baseline characteristics of patients with heart failure with preserved ejection fraction in the EMPEROR‐Preserved trial'
Published in:
European Journal of Heart Failure, 2021, v. 23, n. 5, p. 841, doi. 10.1002/ejhf.2091
By:
- Pabel, Steffen;
- Hamdani, Nazha;
- Sossalla, Samuel
Publication type:
Article
Empagliflozin directly improves diastolic function in human heart failure.
Published in:
2018
By:
- Pabel, Steffen;
- Wagner, Stefan;
- Bollenberg, Hannah;
- Bengel, Philipp;
- Kovács, Árpád;
- Schach, Christian;
- Tirilomis, Petros;
- Mustroph, Julian;
- Renner, André;
- Gummert, Jan;
- Fischer, Thomas;
- Van Linthout, Sophie;
- Tschöpe, Carsten;
- Streckfuss‐Bömeke, Katrin;
- Hasenfuss, Gerd;
- Maier, Lars S.;
- Hamdani, Nazha;
- Sossalla, Samuel;
- Streckfuss-Bömeke, Katrin
Publication type:
journal article
Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure.
Published in:
2018
By:
- Fischer, Thomas H.;
- Eiringhaus, Jörg;
- Dybkova, Nataliya;
- Saadatmand, Alireza;
- Pabel, Steffen;
- Weber, Silvio;
- Wang, Yansong;
- Köhn, Maja;
- Tirilomis, Theodor;
- Ljubojevic, Senka;
- Renner, André;
- Gummert, Jan;
- Maier, Lars S.;
- Hasenfuß, Gerd;
- El‐Armouche, Ali;
- Sossalla, Samuel;
- El-Armouche, Ali
Publication type:
journal article
Simulation of cardiac arrhythmias in human induced pluripotent stem cell-derived cardiomyocytes.
Published in:
PLoS ONE, 2024, v. 19, n. 9, p. 1, doi. 10.1371/journal.pone.0310463
By:
- Bommer, Thea;
- Knierim, Maria;
- Unsöld, Julia;
- Riedl, Dominic;
- Stengel, Laura;
- Paulus, Michael;
- Körtl, Thomas;
- Liaw, Norman;
- Maier, Lars S.;
- Streckfuss-Bömeke, Katrin;
- Sossalla, Samuel;
- Pabel, Steffen
Publication type:
Article
Empagliflozin inhibits Na+/H+ exchanger activity in human atrial cardiomyocytes.
Published in:
ESC Heart Failure, 2020, v. 7, n. 6, p. 4429, doi. 10.1002/ehf2.13024
By:
- Trum, Maximilian;
- Riechel, Johannes;
- Lebek, Simon;
- Pabel, Steffen;
- Sossalla, Samuel T.;
- Hirt, Stephan;
- Arzt, Michael;
- Maier, Lars S.;
- Wagner, Stefan
Publication type:
Article
The oral Ca/calmodulin‐dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure.
Published in:
ESC Heart Failure, 2020, v. 7, n. 5, p. 2871, doi. 10.1002/ehf2.12895
By:
- Mustroph, Julian;
- Drzymalski, Marzena;
- Baier, Maria;
- Pabel, Steffen;
- Biedermann, Alexander;
- Memmel, Bernadette;
- Durczok, Melanie;
- Neef, Stefan;
- Sag, Can Martin;
- Floerchinger, Bernhard;
- Rupprecht, Leopold;
- Schmid, Christof;
- Zausig, York;
- Bégis, Guillaume;
- Briand, Veronique;
- Ozoux, Marie‐Laure;
- Tamarelle, Dorothee;
- Ballet, Veronique;
- Janiak, Philip;
- Beauverger, Philippe
Publication type:
Article
The functional consequences of sodium channel NaV1.8 in human left ventricular hypertrophy.
Published in:
ESC Heart Failure, 2019, v. 6, n. 1, p. 154, doi. 10.1002/ehf2.12378
By:
- Ahmad, Shakil;
- Tirilomis, Petros;
- Pabel, Steffen;
- Dybkova, Nataliya;
- Hartmann, Nico;
- Molina, Cristina E.;
- Tirilomis, Theodoros;
- Kutschka, Ingo;
- Frey, Norbert;
- Maier, Lars S.;
- Hasenfuss, Gerd;
- Streckfuss‐Bömeke, Katrin;
- Sossalla, Samuel
Publication type:
Article
Empagliflozin reduces Ca/calmodulin‐dependent kinase II activity in isolated ventricular cardiomyocytes.
Published in:
ESC Heart Failure, 2018, v. 5, n. 4, p. 642, doi. 10.1002/ehf2.12336
By:
- Mustroph, Julian;
- Wagemann, Olivia;
- Lücht, Charlotte M.;
- Trum, Maximilian;
- Hammer, Karin P.;
- Sag, Can Martin;
- Lebek, Simon;
- Tarnowski, Daniel;
- Reinders, Jörg;
- Perbellini, Filippo;
- Terracciano, Cesare;
- Schmid, Christof;
- Schopka, Simon;
- Hilker, Michael;
- Zausig, York;
- Pabel, Steffen;
- Sossalla, Samuel T.;
- Schweda, Frank;
- Maier, Lars S.;
- Wagner, Stefan
Publication type:
Article
Enhanced Heart Failure in Redox-Dead Cys17Ser PKARIα Knock-In Mice.
Published in:
2021
By:
- Towhidul Islam, M. M.;
- Tarnowski, Daniel;
- Min Zhang;
- Trum, Maximilian;
- Lebek, Simon;
- Mustroph, Julian;
- Daniel, Henriette;
- Moellencamp, Johanna;
- Pabel, Steffen;
- Sossalla, Samuel;
- El-Armouche, Ali;
- Nikolaev, Viacheslav O.;
- Shah, Ajay M.;
- Eaton, Philip;
- Maier, Lars S.;
- Sag, Can Martin;
- Wagner, Stefan;
- Islam, M M Towhidul;
- Zhang, Min
Publication type:
journal article
Electrophysiological and calcium-handling development during long-term culture of human-induced pluripotent stem cell-derived cardiomyocytes.
Published in:
Basic Research in Cardiology, 2023, v. 118, n. 1, p. 1, doi. 10.1007/s00395-022-00973-0
By:
- Seibertz, Fitzwilliam;
- Sutanto, Henry;
- Dülk, Rebekka;
- Pronto, Julius Ryan D.;
- Springer, Robin;
- Rapedius, Markus;
- Liutkute, Aiste;
- Ritter, Melanie;
- Jung, Philipp;
- Stelzer, Lea;
- Hüsgen, Luisa M.;
- Klopp, Marie;
- Rubio, Tony;
- Fakuade, Funsho E.;
- Mason, Fleur E.;
- Hartmann, Nico;
- Pabel, Steffen;
- Streckfuss-Bömeke, Katrin;
- Cyganek, Lukas;
- Sossalla, Samuel
Publication type:
Article
Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions.
Published in:
Basic Research in Cardiology, 2022, v. 117, n. 1, p. 1, doi. 10.1007/s00395-022-00949-0
By:
- Paulus, Michael G.;
- Renner, Kathrin;
- Nickel, Alexander G.;
- Brochhausen, Christoph;
- Limm, Katharina;
- Zügner, Elmar;
- Baier, Maria J.;
- Pabel, Steffen;
- Wallner, Stefan;
- Birner, Christoph;
- Luchner, Andreas;
- Magnes, Christoph;
- Oefner, Peter J.;
- Stark, Klaus J.;
- Wagner, Stefan;
- Maack, Christoph;
- Maier, Lars S.;
- Streckfuss-Bömeke, Katrin;
- Sossalla, Samuel;
- Dietl, Alexander
Publication type:
Article
Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients.
Published in:
Basic Research in Cardiology, 2022, v. 117, n. 1, p. 1, doi. 10.1007/s00395-022-00918-7
By:
- Haupt, Luis Peter;
- Rebs, Sabine;
- Maurer, Wiebke;
- Hübscher, Daniela;
- Tiburcy, Malte;
- Pabel, Steffen;
- Maus, Andreas;
- Köhne, Steffen;
- Tappu, Rewati;
- Haas, Jan;
- Li, Yun;
- Sasse, Andre;
- Santos, Celio C. X.;
- Dressel, Ralf;
- Wojnowski, Leszek;
- Bunt, Gertrude;
- Möbius, Wiebke;
- Shah, Ajay M.;
- Meder, Benjamin;
- Wollnik, Bernd
Publication type:
Article
Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice.
Published in:
Basic Research in Cardiology, 2020, v. 115, n. 2, p. 1, doi. 10.1007/s00395-020-0780-8
By:
- Pabel, Steffen;
- Ahmad, Shakil;
- Tirilomis, Petros;
- Stehle, Thea;
- Mustroph, Julian;
- Knierim, Maria;
- Dybkova, Nataliya;
- Bengel, Philipp;
- Holzamer, Andreas;
- Hilker, Michael;
- Streckfuss-Bömeke, Katrin;
- Hasenfuss, Gerd;
- Maier, Lars S.;
- Sossalla, Samuel
Publication type:
Article
Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes.
Published in:
Journal of Molecular Medicine, 2020, v. 98, n. 12, p. 1689, doi. 10.1007/s00109-020-01989-6
By:
- Pabel, Steffen;
- Reetz, Florian;
- Dybkova, Nataliya;
- Shomroni, Orr;
- Salinas, Gabriela;
- Mustroph, Julian;
- Hammer, Karin P.;
- Hasenfuss, Gerd;
- Hamdani, Nazha;
- Maier, Lars S.;
- Streckfuss-Bömeke, Katrin;
- Sossalla, Samuel
Publication type:
Article
Potential Mechanisms of SGLT2 Inhibitors for the Treatment of Heart Failure With Preserved Ejection Fraction.
Published in:
Frontiers in Physiology, 2021, v. 12, p. 1, doi. 10.3389/fphys.2021.752370
By:
- Pabel, Steffen;
- Hamdani, Nazha;
- Singh, Jagdeep;
- Sossalla, Samuel
Publication type:
Article
Comparative Analysis of Mitochondria Surrounding the Intercalated Discs in Heart Diseases—An Ultrastructural Pilot Study.
Published in:
International Journal of Molecular Sciences, 2024, v. 25, n. 14, p. 7644, doi. 10.3390/ijms25147644
By:
- Schönmehl, Rebecca;
- Mendelsohn, Daniel H.;
- Winter, Lina;
- Pabel, Steffen;
- Niedermair, Tanja;
- Evert, Katja;
- Cheung, Wing-Hoi;
- Wong, Ronald Man Yeung;
- Schmitt, Volker H.;
- Keller, Karsten;
- Barsch, Friedrich;
- Dietl, Alexander;
- Gummert, Jan F.;
- Schramm, René;
- Sossalla, Samuel;
- Brochhausen, Christoph
Publication type:
Article

Found: 24

Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias.

Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure.

Structural Analysis of Mitochondrial Dynamics—From Cardiomyocytes to Osteoblasts: A Critical Review.

Detrimental proarrhythmogenic interaction of Ca<sup>2+</sup>/calmodulin-dependent protein kinase II and Na<sub>V</sub>1.8 in heart failure.

Empagliflozin enhances human and murine cardiomyocyte glucose uptake by increased expression of GLUT1.

Atrial fibrillation and heart failure: novel insights into the chicken and egg dilemma.

Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart.

Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation.

A mechanistic rationale for the investigation of sodium–glucose co‐transporter 2 inhibitors in heart failure with preserved ejection fraction. Letter regarding the article 'Baseline characteristics of patients with heart failure with preserved ejection fraction in the EMPEROR‐Preserved trial'

Empagliflozin directly improves diastolic function in human heart failure.

Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca<sup>2+</sup> leak in human heart failure.

Simulation of cardiac arrhythmias in human induced pluripotent stem cell-derived cardiomyocytes.

Empagliflozin inhibits Na<sup>+</sup>/H<sup>+</sup> exchanger activity in human atrial cardiomyocytes.

The oral Ca/calmodulin‐dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure.

The functional consequences of sodium channel Na<sub>V</sub>1.8 in human left ventricular hypertrophy.

Empagliflozin reduces Ca/calmodulin‐dependent kinase II activity in isolated ventricular cardiomyocytes.

Enhanced Heart Failure in Redox-Dead Cys17Ser PKARIα Knock-In Mice.

Electrophysiological and calcium-handling development during long-term culture of human-induced pluripotent stem cell-derived cardiomyocytes.

Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions.

Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients.

Inhibition of Na<sub>V</sub>1.8 prevents atrial arrhythmogenesis in human and mice.

Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes.

Potential Mechanisms of SGLT2 Inhibitors for the Treatment of Heart Failure With Preserved Ejection Fraction.

Comparative Analysis of Mitochondria Surrounding the Intercalated Discs in Heart Diseases—An Ultrastructural Pilot Study.