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- Title
International validation of the EORTC QLQ-PRT20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase IV study.
- Authors
Halkett, Georgia K. B.; Wigley, Charles Adam; Aoun, Samar M; Portaluri, Maurizio; Tramacere, Francesco; Livi, Lorenzo; Detti, Beatrice; Arcangeli, Stefano; Lund, Jo-Asmund; Kristensen, Are; McFadden, Nathalie; Grun, Arne; Bydder, Sean; Sackerer, Irina; Greimel, Elfriede; Spry, Nigel; EORTC Quality of Life Group
- Abstract
<bold>Background: </bold>Although patients experience radiation proctitis post radiotherapy no internationally tested instruments exist to measure these symptoms. This Phase IV study tested the scale structure, reliability and validity and cross-cultural applicability of the EORTC proctitis module (QLQ-PRT23) in patients who were receiving pelvic radiotherapy.<bold>Methods: </bold>Patients (n = 358) from six countries completed the EORTC QLQ-C30, QLQ-PRT23 and EORTC Quality of Life Group debriefing questions. Clinicians completed the EORTC Radiation Therapy Oncology Group scale. Questionnaires were completed at four time-points. The module's scale structure was examined and validated using standard psychometric analysis techniques.<bold>Results: </bold>Three items were dropped from the module (QLQ-PRT23 → QLQ-PRT20). Factor analysis identified five factors in the module: bowel control; bloating and gas; emotional function/lifestyle; pain; and leakage. Inter-item correlations were within r = 0.3-0.7. Test-Retest reliability was high. All multi-item scales discriminated between patients showing symptoms and those without symptomology. The module discriminated symptoms from the clinician completed scoring and for age, gender and comorbidities.<bold>Conclusion: </bold>The EORTC QLQ-PRT20 is designed to be used in addition to the EORTC QLQ-C30 to measure quality of life in patients who receive pelvic radiotherapy. The EORTC QLQ-PRT20 is quick to complete, acceptable to patients, has good content validity and high reliability.<bold>Trial Registration: </bold>Australian and New Zealand Clinical Trials Registry (ANZCTR) ACTRN12609000972224 .
- Subjects
RADIOTHERAPY; QUALITY of life; PROSTATE cancer patients; PROSTATE cancer treatment; MEDICAL quality control
- Publication
Radiation Oncology, 2018, Vol 13, Issue 1, pN.PAG
- ISSN
1748-717X
- Publication type
journal article
- DOI
10.1186/s13014-018-1107-x