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- Title
Pulmonary fibrosis in a dog as a sequela of infection with Severe Acute Respiratory Syndrome Coronavirus 2? A case report.
- Authors
Colitti, Barbara; Manassero, Luca; Colombino, Elena; Ferraris, Erica Ilaria; Caccamo, Roberta; Bertolotti, Luigi; Bortolami, Alessio; Bonfante, Francesco; Papa, Valentina; Cenacchi, Giovanna; Calabrese, Fiorella; Bozzetta, Elena; Varello, Katia; Capucchio, Maria Teresa; Rosati, Sergio
- Abstract
Background: Interstitial lung disease is a heterogeneous group of conditions characterized by severe radiographic changes and clinicopathological findings. However, in the vast majority of cases, the cause remains unknown. Case description: In the present study, we reported the clinical case of a 3 years old female Bull Terrier presented in October 2020 to the Advanced Diagnostic Imaging Department of the Turin Veterinary Teaching Hospital with a progressive pulmonary illness characterized by dyspnea, exercise intolerance, and a diffuse and severe pulmonary interstitial pattern at imaging investigations. Considering the clinical findings, the dog was included in a serological survey for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in companion animals, showing positive results. Due to the further clinical worsening, the owners opted for euthanasia. At necroscopy, dog showed severe and chronic bronchopneumonia compatible with a Canine Idiopathic Pulmonary Fibrosis and with serological features linked to a SARS-CoV-2 infection. Conclusions: The comparison of these lesions with those reported in humans affected by Coronavirus Disease 2019 (COVID-19) supports the hypothesis that these findings may be attributable to the post-acute sequelae of SARS-CoV-2 infection in a dog with breed predisposition to Canine Idiopathic Pulmonary Fibrosis (CIPF), although direct evidence of SARS-CoV-2 by molecular or antigenic approaches remained unsolved.
- Subjects
COVID-19; SARS-CoV-2; POST-acute COVID-19 syndrome; PULMONARY fibrosis; IDIOPATHIC pulmonary fibrosis; INTERSTITIAL lung diseases
- Publication
BMC Veterinary Research, 2022, Vol 18, Issue 1, p1
- ISSN
1746-6148
- Publication type
Article
- DOI
10.1186/s12917-022-03191-x