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- Title
Analysis of the Expression of I--Ak--like Antigens in Murine Fetal and Adult Tissues with the Monoclonal Antibody 10--2.16.
- Authors
Natali, P. G.; de Martino, C.; Pellegrino, M. A.; Ferrone, S.
- Abstract
The expression of I-Ak antigens in normal C3H/FeJ adult and 15-day embryonic mice has been investigated by indirect immunofluorescence staining of tissue cryostat sections with the anti I-Ak antigen monoclonal antibody 10-2.16. In adult mice I-Ak antigens were expressed in Langerhans-like cells in the skin, epithelium of the gastrointestinal tract, endometrium, thymicreticuloepithelial cells, and several capillary endothelia. On the other hand, these antigens were not detected in Kupffer cells, alveolar macrophages, brain or mammary gland. In I5-day-oldembryos the expression of la-like antigens was restricted to thymic reticuloepithelial cells, isolated spleen cells, and capillaries of the gastrointestinal tract.
- Subjects
ANTIGENS; IMMUNITY; TISSUES; MONOCLONAL antibody probes; MONOCLONAL antibodies; CELLS
- Publication
Scandinavian Journal of Immunology, 1981, Vol 13, Issue 6, p541
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1981.tb00167.x