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- Title
Differential Role of Zn<sup>2</sup>+ in Antigen- and Mitogen-induced Lymphokine Production.
- Authors
Bendtzen, K.
- Abstract
The effect on human lymphokine production in vitro of phenanthroline, a Zn2+-chelating agent and an inhibitor of carboxypeptidases A and H, was tested. The elaboration of leucocyte migration inhibitory factor (LIF) by tuberculin-sensitized mononuclear cells stimulated with the specific antigen was reduced in a dose-dependent manner, an effect completely restored by addition of excess Zn2+. In contrast, phenanthroline did not affect LIP production by mononuclear cells activated nonspecifically by phytohaemagglutinin. It is hypothesized that the presence of a Zn2+-dependent molecule, possibly a carboxypeptidase, may be necessary for antigen- but not for mitogen-induced lymphokine production.
- Subjects
LYMPHOKINES; INTERFERONS; MITOGENS; LECTINS; BACTERIAL antigens; TUBERCULIN
- Publication
Scandinavian Journal of Immunology, 1980, Vol 12, Issue 6, p489
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1980.tb00095.x