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- Title
Serial studies of methylation of CDKN2B and CDKN2A in relapsed acute promyelocytic leukaemia treated with arsenic trioxide.
- Authors
Wing-Yan Au; Fung, Alvin T.; Ma, Edmond S.; Cheuk-Hung Chan; Kit-Fai Wong; Chor-Sang Chim; Liang, Raymond H.; Yok-Lam Kwong
- Abstract
Ninety consecutive patients with acute promyelocytic leukaemia were investigated for promoter methylation of CDKN2B (alias p15) and CDKN2A (alias p16) in disease relapse and progression. CDKN2B methylation was significantly more frequent at first relapse (30/36, 83%) than at presentation (48/77, 62%) ( P = 0·025), while CDKN2A methylation appeared unaffected. Both acquisition and loss of CDKN2B methylation happened at relapse, with acquisition more frequent. No significant increase in CDKN2B and CDKN2A methylation occurred at more advanced relapses. At first or subsequent relapses, owing to highly effective salvage by arsenic trioxide, CDKN2B methylation did not impact on event-free survival or overall survival.
- Subjects
ACUTE leukemia; METHYLATION; ALKYLATION; ARSENIC compounds; PATIENTS; LEUKEMIA
- Publication
British Journal of Haematology, 2005, Vol 131, Issue 5, p632
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2005.05818.x