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- Title
Hypoplastic myelodysplastic syndromes can be distinguished from acquired aplastic anaemia by bone marrow stem cell expression of the tumour necrosis factor receptor.
- Authors
Kasahara, Senji; Hara, Takeshi; Itoh, Hiroyasu; Ando, Kazuki; Tsurumi, Hisashi; Sawada, Michio; Yamada, Toshiki; Ohnishi, Hiroo; Moriwaki, Hisataka
- Abstract
Summary. It is often difficult to distinguish hypoplastic myelodysplastic syndrome (h-MDS) from acquired aplastic anaemia (AA), because of the considerable clinical, cytological and histological similarities between these two disorders. The distinction between AA and h-MDS is important because there is a higher risk of progression to acute leukaemia in patients with h-MDS compared with AA. Recent studies suggest that tumour necrosis factor-alpha (TNF-α) plays an important role in the development of AA. In order to determine the potential importance of TNF-α in the differential diagnosis of hypoplastic bone marrow (BM) disorders, we examined whether analysis ofTNF-receptor expression could be used as a tool to differentiate AA from h-MDS. Flow cytometric analysis revealed that BM stem cells (CD34+ ) from AA patients have markedly greater TNF receptor (R) 1 and TNFR2 expression than those from patients with MDS and h-MDS. We suggest that the BM stem cells with a high expression of TNFR in patients with AA may be potently sensitive to TNF-α stimulation of differentiation. Thus, we propose that quantification of TNFR expression in BM stem cellsmay be a useful method to distinguish AA from h-MDS.
- Subjects
MYELODYSPLASTIC syndromes; APLASTIC anemia; BONE marrow; STEM cells; TUMOR necrosis factors
- Publication
British Journal of Haematology, 2002, Vol 118, Issue 1, p181
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2002.03592.x