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- Title
Patchy Cecal Inflammation Associated with Distal Ulcerative Colitis: A Prospective Endoscopic Study.
- Authors
D'Haens, Geert; Geboes, Karel; Peeters, Marc; Baert, Filip; Ectors, Nadine; Rutgeerts, Paul
- Abstract
Objectives: It is generally believed that the mucosal inflammation in ulcerative colitis is characterized by a diffuse, continuous involvement starting from the rectum without "skip areas." It was the aim of this study to examine 20 patients with established "left-sided ulcerative colitis" prospectively by ileocolonoscopy with biopsies to determine the extent and the continuity of the mucosal inflammation and the incidence of skip lesions in ulcerative colitis. Methods: Twenty. patients with left-sided ulcerative colitis underwent a complete ileocolonoscopy with biopsies of the terminal ileum and all colonic segments. The patients remained in clinical follow-up for at least 8 yr after the initial examination. Results: The upper margin of inflammation was sharply demarcated in 6 patients and gradual in 14. Segmental inflammation, separated from the distal inflamed segment by apparently uninvolved mucosa, was found in 15 patients (75%) and always included the area around the appendiceal orifice. The correlation between endoscopic abnormalities and histological changes was excellent. Conclusion: In so-called "left-sided" ulcerative colitis distal involvement may be accompanied by more proximal areas of inflammation, particularly in the periappendiceal area of the cecum.
- Subjects
INFLAMMATORY bowel diseases; ULCERATIVE colitis; COLONOSCOPY; BIOPSY; GASTROENTEROLOGY
- Publication
American Journal of Gastroenterology (Springer Nature), 1997, Vol 92, Issue 8, p1275
- ISSN
0002-9270
- Publication type
Article