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- Title
Biological Monitoring of Hexavalent Chromium and Serum Levels of the Senescence Biomarker Apolipoprotein J/Clusterin in Welders.
- Authors
Alexopoulos, Evangelos C.; Cominos, Xenophon; Trougakos, Ioannis P.; Lourda, Magda; Gonos, Efstathios S.; Makropoulos, Vassilios
- Abstract
Welding fumes contain metals and other toxic substances known or strongly suspected to be related with oxidative stress and premature cellular senescence. Apolipoprotein J/Clusterin (ApoJ/CLU) is a glycoprotein that is differentially regulated in various physiological and disease states including ageing and age-related diseases. In vitro data showed that exposure of human diploid fibroblasts to hexavalent chromium (Cr(VI)) resulted in premature senescence and significant upregulation of the ApoJ/CLU protein. In this study we analyzed blood and urine samples from shipyard industry welders being exposed to different levels of Cr(VI) over a period of five months in order to assay in vivo the relation of ApoJ/CLU serum levels with Cr(VI). Our findings confirmed the previously reported in vitro data since reduction of Cr levels, after a worksite intervention, associated with lower levels of ApoJ/CLU serum levels. We concluded that the human ApoJ/CLU gene is responsive to the acute in vivo oxidative stress induced by heavy metals such as hexavalent chromium.
- Subjects
HEXAVALENT chromium; BIOMARKERS; SERUM; APOLIPOPROTEINS; CLUSTERIN; WELDERS (Persons)
- Publication
Bioinorganic Chemistry & Applications, 2008, p1
- ISSN
1565-3633
- Publication type
Article
- DOI
10.1155/2008/420578