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- Title
Intensive chemotherapy with idarubicin, ara-C, etoposide, and m-AMSA followed by immunotherapy with interleukin-2 for myelodysplastic syndromes and high-risk Acute Myeloid Leukemia (AML).
- Authors
Ganser, A.; Heil, G.; Seipelt, G.; Hofmann, W.; Fischer, J. T.; Langer, W.; Brockhaus, W.; Kolbe, K.; Ittel, T. H.; Brack, N.; Fuhr, H. G.; Knuth, P.; Höffken, K.; Bergmann, L.; Hoelzer, D.; Höffken, K
- Abstract
Intensive chemotherapy followed by treatment with interleukin-2 (IL-2) was evaluated in a prospective, randomized, multicenter trial including 18 patients with refractory anemia with excess of blasts in transformation (RAEB-T), 86 patients with acute myeloid leukemia (AML) evolving from myelodysplastic syndromes, and six patients with secondary AML after previous chemotherapy. Median age was 58 years (range: 18-76 years). Forty-nine patients (45%) achieved a complete remission (CR) after two induction cycles with idarubicin, ara-C, and etoposide, 52% of them aged </=60 years and 35% aged >60 years (p=0.06). After two consolidation courses, patients were randomized to four cycles of either high- or low-dose IL-2. Patients aged up to 55 years with an HLA-identical sibling donor were eligible for allogeneic bone marrow transplantation. The median relapse-free survival was 12.5 months, with a probability of ongoing CR at 6.5 years of 19%. Overall survival of all patients was 8 months, and 21 months for the CR patients. Median survival was significantly longer among patients aged </=60 years than among the older patients (16 vs 6 months, p<0.001). Median duration of survival and relapse-free survival were not statistically different in the two IL-2 treatment arms.
- Subjects
DRUG therapy; MYELODYSPLASTIC syndromes; CHRONIC myeloid leukemia; INTERLEUKIN-2; IMMUNOTHERAPY; ETOPOSIDE
- Publication
Annals of Hematology, 2000, Vol 79, Issue 1, p30
- ISSN
0939-5555
- Publication type
journal article
- DOI
10.1007/s002770050005