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- Title
Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup
- Authors
Sperling, Reisa A.; Jack, Clifford R.; Black, Sandra E.; Frosch, Matthew P.; Greenberg, Steven M.; Hyman, Bradley T.; Scheltens, Philip; Carrillo, Maria C.; Thies, William; Bednar, Martin M.; Black, Ronald S.; Brashear, H. Robert; Grundman, Michael; Siemers, Eric R.; Feldman, Howard H.; Schindler, Rachel J.
- Abstract
Abstract: Amyloid imaging related abnormalities (ARIA) have now been reported in clinical trials with multiple therapeutic avenues to lower amyloid-β burden in Alzheimer’s disease (AD). In response to concerns raised by the Food and Drug Administration, the Alzheimer’s Association Research Roundtable convened a working group to review the publicly available trial data, attempts at developing animal models, and the literature on the natural history and pathology of related conditions. The spectrum of ARIA includes signal hyperintensities on fluid attenuation inversion recoverysequences thought to represent “vasogenic edema” and/or sulcal effusion (ARIA-E), as well as signal hypointensities on GRE/T2∗ thought to represent hemosiderin deposits (ARIA-H), including microhemorrhage and superficial siderosis. The etiology of ARIA remains unclear but the prevailing data support vascular amyloid as a common pathophysiological mechanism leading to increased vascular permeability. The workgroup proposes recommendations for the detection and monitoring of ARIA in ongoing AD clinical trials, as well as directions for future research.
- Subjects
AMYLOID beta-protein; ALZHEIMER'S disease treatment; MEDICAL conferences; CEREBRAL hemorrhage; EDEMA; ETIOLOGY of diseases
- Publication
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2011, Vol 7, Issue 4, p367
- ISSN
1552-5260
- Publication type
Article
- DOI
10.1016/j.jalz.2011.05.2351