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- Title
Effects of Isopsoralen Plus Zinc on Proliferation and Differentiation of Cultured Osteoblasts in vitro.
- Authors
ZHANG Jun-fang; GUO Min; WANG Jian-hua
- Abstract
To study the effects of isopsoralen plus zinc on proliferation and differentiation of cultured osteoblasts in vitro, MTF and PNPP were used separately to observe .the proliferation and the activity of ALP of osteoblasts cultured in vitro with isopsoralen plus zinc of different concentration in it for different incubation periods. The effect of promoting proliferation of rat osteoblast cells in vitro after 24 and 48 h was more marked by the groups of isopsoralen plus zinc compared with the simple application of isopsoralen or zinc sulfate. The activity of alkaline phosphate (ALP) was stimulated by isopsoralen and zinc after 48 and 72 h incubation. It was demonstrated that combination of isopsoralen and zinc could synergistically enhance the proliferation and differentiation of cultured osteoblasts in vitro.
- Subjects
ZINC; CELL proliferation; CELL differentiation; ZINC sulfate; PHOSPHATES
- Publication
Natural Product Research & Development, 2009, Vol 21, Issue 3, p409
- ISSN
1001-6880
- Publication type
Article