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- Title
Serum Total Immunoglobulin E Is a Surrogate of Atopy in Adult-Onset Asthma: A Longitudinal Study.
- Authors
Carsin, anne-Elie; Zock, Jan-Paul; Jarvis, Deborah; Basagaña, Xavier; Heinrich, Joachim; Toren, Kjell; Janson, Christer; anto, Josep Maria; Sunyer, Jordi
- Abstract
Background: Studies have shown that serum total immunoglobulin E (IgE) levels are higher in asthmatics. However, the role of the serum total IgE level, independently from atopy, in adult asthma is not understood. We studied the associations between serum total IgE, the number of sensitizations and the sum of specific IgEs and new-onset asthma using longitudinal data from the European Community Respiratory Health Survey. Methods: Serum total and specific IgE to 4 common inhalant allergens were measured at baseline in 9,175 participants, with a follow-up of 9 years. Individuals with asthma history and/or asthma symptoms were excluded. Atopy was defined as the presence of at least one specific IgE ≥0.35 kU/l. Total and specific IgEs were regressed against new-onset asthma using multivariate logistic regression with a random intercept for the study centre. Results: Two hundred and ninety-seven participants had developed asthma during follow-up (incidence rate 5.7 per 1,000 person-years). A 10% higher level of total IgE was associated with a 12% increased risk of new-onset asthma (p = 0.005). However, after adjustment for the number of positive specific IgEs
- Subjects
EUROPE; ASTHMA; ATOPY; IMMUNOGLOBULIN E; HEALTH surveys
- Publication
International Archives of Allergy & Immunology, 2013, Vol 160, Issue 4, p387
- ISSN
1018-2438
- Publication type
Article
- DOI
10.1159/000342464