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- Title
Bladder Carcinoma Associated with BK Virus in a Renal Allograft Recipient.
- Authors
Gaur, L.; Gupta, A.; Meena, P.; Shingada, A.; Gupta, P.; Rana, D. S.
- Abstract
Bladder carcinoma is a relatively rare carcinoma reported in renal allograft recipients. While many oncogenic viruses have been implicated as causative factors for certain malignancies, questions have been raised about possible role of BK virus in pathogenesis of urothelial cancers. In this report, we have described a patient who developed BK virus nephropathy followed 3 years later by bladder carcinoma. Interestingly, while the tumor tissue demonstrated BK virus, the adjacent normal urothelium was stained negative for BK virus. Considering the viral potential to inhibit tumor suppressors and its differential localization within tumor tissue, it is possible that the virus contributes to tumorigenesis.
- Subjects
POLYOMAVIRUS diseases; BLADDER tumors; EPITHELIUM; HOMOGRAFTS; KIDNEYS; KIDNEY transplantation; TRANSPLANTATION of organs, tissues, etc.; POLYOMAVIRUSES; DIAGNOSIS
- Publication
Indian Journal of Nephrology, 2019, Vol 29, Issue 2, p135
- ISSN
0971-4065
- Publication type
Article
- DOI
10.4103/ijn.IJN_434_17