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- Title
Understanding the Molecular Mechanism of Interventions in Treating Rheumatoid Arthritis Patients with Corresponding Traditional Chinese Medicine Patterns Based on Bioinformatics Approach.
- Authors
Miao Jiang; Cheng Lu; Gao Chen; Cheng Xiao; Qinglin Zha; Xuyan Niu; Shilin Chen; Aiping Lu
- Abstract
Better effectiveness would be achieved when interventions are used in treating patients with a specific traditional Chinese medicine (TC M) pattern. In this paper, the effectiveness in treating rheumatoid arthritis (RA) patients in a randomized clinical trial as reanalyzed after the patients were classified into different TC M patterns and the underlying mechanism of how the TC M pattern influences the clinical effectiveness of interventions (TC M and biomedicine therapy) was explored. The pharmacological networks of interventions were builtup with protein and protein interaction analyses based on all the related targeted proteins obtained from Pub Chem. The underlying mechanism was explored by merging the pharmacological networks with the molecular networks of TC M cold and hot patterns in RA. The results show that the TC M therapy is better in treating the RA patients with TC M hot pattern, and the biomedical therapy is better in the RA patients with cold pattern. The pharmacological network of TC M intervention is merged well with the molecular network of TC M hot pattern, and the pharmacological network of biomedical therapy is merged well with the network of cold pattern. The finding indicates that molecular network analysis could give insight into the full understanding of the underlying mechanism of how TC M pattern impacts the efficacy.
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2012, Vol 2012, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2012/129452