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- Title
Synthesis of 3,4,5-Trisubstituted Isoxazoles through Gold-Catalyzed Cascade Cyclization--Oxidative Alkynylation and Cyclization-Fluorination of 2-Alkynone O-Methyloximes.
- Authors
Doo-Hee Song; Jae-Sang Ryu
- Abstract
Gold-catalyzed tandem cyclization--oxidative alkynylation and cyclization-fluorination reactions of 2-alkynone O-methyloximes are described. The reactions proceed smoothly at room temperature in the presence of 10 mol % of (PPh3)AuNTf2, 2.5 equivalents of selectfluor, and 2 equivalents of K3PO4. 2-Alkynone O-methyloximes undergo intramolecular oxyauration/cyclization and ensuing oxidative cross-coupling and fluorination process to afford the corresponding 3,4,5-trisubstituted isoxazoles in a cascade manner.
- Subjects
RING formation (Chemistry); GOLD; INTRAMOLECULAR catalysis; FLUORINATION; ISOXAZOLES
- Publication
Bulletin of the Korean Chemical Society, 2014, Vol 35, Issue 9, p2635
- ISSN
0253-2964
- Publication type
Article
- DOI
10.5012/bkcs.2014.35.9.2635