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- Title
Identification of SACE_7040, a Member of TetR Family Related to the Morphological Differentiation of Saccharopolyspora erythraea.
- Authors
Han, Shu; Song, Ping; Ren, Ting; Huang, Xunduan; Cao, Cheng; Zhang, Buchang
- Abstract
SACE_7040 is presumed to be a member of the TetR family of transcriptional regulators in Saccharopolyspora erythraea, but its biological function is unknown. It was shown that the SACE_7040 gene knockout mutant formed aerial mycelium earlier than its original strain, and this phenotype could be restored by complementation of a single copy of SACE_7040 gene, demonstrating that SACE_7040 is an important regulator of the morphological differentiation of Sac. erythraea. When SACE_7040 gene was disrupted in the bldD mutant, we intriguingly found that the defect in aerial development exhibited by the bldD mutant could be overcome, suggesting a crosstalk between SACE_7040 and BldD in Sac. erythraea morphogenesis. These findings provide novel insights toward the Sac. erythraea developmental biology.
- Subjects
MYCELIUM; PHENOTYPES; MORPHOGENESIS; DEVELOPMENTAL biology; BACTERIAL diseases
- Publication
Current Microbiology, 2011, Vol 63, Issue 2, p121
- ISSN
0343-8651
- Publication type
Article
- DOI
10.1007/s00284-011-9943-z