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- Title
Quantitative analysis of choroidal blood flow parameters in optical coherence tomography and angiography in central serous chorioretinopathy.
- Authors
Hwang, Bo-Een; Kwak, Jae-Hyuck; Kim, Joo-Young; Kim, Rae-Young; Kim, Mirinae; Park, Young-Geun; Park, Young-Hoon
- Abstract
Purpose: To evaluate the choriocapillaris (CC) flow in central serous chorioretinopathy (CSC) and determine the relationship between CC flow void with the choroidal thickness (CT) and choroidal vascularity index (CVI). Methods: Retrospective analysis of 20 patients with CSC (40 eyes, including unaffected fellow eyes) and 20 age- and sex-matched controls. After compensation with optical coherence tomography (OCT) en-face structural image, the CC flow void (%) was measured using the phansalkar threshold with a window radius of 3 and 15 pixels. The mean CC flow voids of acute CSC, recovered-acute CSC, unaffected fellow, and control eyes were compared by matched data analysis. A regression analysis was performed on the choroidal parameters (CT and CVI) and CC flow voids. Results: The CC flow void had an increasing tendency in the following order: control, fellow, recovered-acute CSC, and acute CSC eyes. Acute/recovered comparison showed a significant P value (0.008) in the foveal lesion. Recovered/fellow and fellow/control presented significant P values regardless of location to fovea (all <0.05). There were significant positive correlations between CT and CC flow void (P < 0.05) in the acute CSC, recovered-acute CSC eyes. Conclusion: The CC flow on OCT angiography decreased in acute CSC eyes, especially in the foveal lesion, with a published compensation method. The findings suggest that unmodulated choroidal blood flow contributed to partially reversible diminished CC flow.
- Subjects
OPTICAL coherence tomography; BLOOD flow; OPTICAL flow; BLOOD testing; CHOROID
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2022, Vol 260, Issue 7, p2111
- ISSN
0721-832X
- Publication type
Article
- DOI
10.1007/s00417-022-05588-8