We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Clinicopathologic features of orbital immunoglobulin G4-related disease (IgG4-RD): a case series and literature review.
- Authors
Mulay, Kaustubh; Aggarwal, Ekta; Honavar, Santosh
- Abstract
Background: Involvement of orbital structures by immunoglobulin G4-related disease (IgG4-RD) is not uncommon. We conducted this study to evaluate the clinicopathologic features of orbital IgG4-RD. Material/Methods: This was a retrospective, clinicopathologic study. Clinical records, light microscopic features, results of immunostaining with IgG & IgG4 and laboratory findings were reviewed in 16 patients diagnosed with orbital IgG4-RD. Results: Eleven patients had a bilateral disease, and the lacrimal gland was involved in 14. Dense sclerosis, plasma cell aggregates and dense lymphoplasmacytic infiltrate were seen in all patients. Serum IgG4 titre was elevated in 12 patients. Nine patients responded completely to glucocorticoid treatment. Five patients had a relapse on discontinuation of treatment. Conclusion: Orbital IgG4-RD is a distinct clinicopathologic entity requiring increased awareness and needs to be differentiated from other orbital lymphoproliferative lesions.
- Subjects
EYE diseases; IMMUNOGLOBULINS; EYE proteins; IMMUNOSTAINING; MEDICAL literature reviews; RETROSPECTIVE studies; PATIENTS
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2015, Vol 253, Issue 5, p803
- ISSN
0721-832X
- Publication type
Article
- DOI
10.1007/s00417-014-2905-y