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- Title
Cerebral metabolic changes in neurologically presymptomatic patients undergoing haemodialysis: in vivo proton MR spectroscopic findings.
- Authors
Chiu ML; Li CW; Chang JM; Chiang IC; Ko CH; Chuang HY; Sheu RS; Lee CC; Hsieh TJ; Chiu, Ming-Lun; Li, Chun-Wei; Chang, Jer-Ming; Chiang, I-Chan; Ko, Chih-Hung; Chuang, Hung-Yi; Sheu, Reu-Sheng; Lee, Chen-Chang; Hsieh, Tsyh-Jyi
- Abstract
<bold>Objective: </bold>To prospectively investigate and detect early cerebral metabolic changes in patients with end-stage renal disease (ESRD) by using in vivo proton MR spectroscopy (MRS).<bold>Methods: </bold>We enrolled 32 patients with ESRD and 32 healthy controls between the ages of 26 and 50 years. Short echo time single-voxel proton MRS was acquired from volumes of interest (VOIs) located in the frontal grey and white matter, temporal white matter and basal ganglia. The choline/phospatidylcholine (Cho), myo-inositol (mI), N-acetylaspartate (NAA) and total creatine (tCr) peaks were measured and the metabolic ratios with respect to tCr were calculated.<bold>Results: </bold>In the ESRD group, significant elevations of the Cho/tCr and mI/tCr ratios were observed for the frontal grey matter, frontal white matter, temporal white matter and basal ganglia as compared with controls. There was no significant difference in the NAA/tCr ratios at all VOIs between the ESRD patients and the healthy controls.<bold>Conclusions: </bold>Proton MRS is a useful and non-invasive imaging tool for the detection of early cerebral metabolic changes in neurologically presymptomatic ESRD patients.
- Publication
European Radiology, 2010, Vol 20, Issue 6, p1502
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-009-1673-2