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- Title
Quantification of aortic distensibility in abdominal aortic aneurysm using ECG-gated multi-detector computed tomography.
- Authors
Ganten MK; Krautter U; von Tengg-Kobligk H; Böckler D; Schumacher H; Stiller W; Delorme S; Kauczor HU; Kauffmann GW; Bock M; Ganten, Maria-Katharina; Krautter, Ute; von Tengg-Kobligk, Hendrik; Böckler, Dittmar; Schumacher, Hardy; Stiller, Wolfram; Delorme, Stefan; Kauczor, Hans-Ulrich; Kauffmann, Günter W; Bock, Michael
- Abstract
<bold>Rationale and Objectives: </bold>To detect distensibility changes that might be an indicator for an increased risk of rupture, cross-sectional area changes of abdominal aortic aneurysms (AAA) have been determined using ECG-gated CT.<bold>Materials and Methods: </bold>Distensibility measurements of the aorta were performed in 67 patients with AAA. Time-resolved images were acquired with a four detector-row CT system using a modified CT-angiography protocol. Pulsatility-related cross-sectional area changes were calculated above and at AAA level by semiautomatic segmentation; distensibility values were obtained using additional systemic blood pressure measurements. Values were compared for small Ø<5 cm (n=44) and large Ø>5 cm (n=23) aneurysms.<bold>Results: </bold>The aorta could be segmented successfully in all patients. Upstream AAA distensibility D was significantly higher than at AAA level for both groups: means above AAA (at AAA) D(above)=(1.3+/-0.8) x 10(-5) Pa(-1) (D(AAA )=(0.6+/-0.5) x 10(-5) Pa(-1)) t-test p(D)<0.0001. Differences of the distensibility between smaller and larger aneurysms were not found to be significant.<bold>Conclusion: </bold>Distensibility can be measured non-invasively with ECG-gated CT. The reduction of distensibility within aneurysms compared to normal proximal aorta is subtle; the lack of difference between both small and large aneurysms suggests that this reduction occurs early in the aneurysm's development. Hence, reduced distensibility might be a predictive parameter in patients with high risk of aortic disease.
- Publication
European Radiology, 2008, Vol 18, Issue 5, p966
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-007-0833-5