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- Title
Differences in phenotypic and genotypic traits against antimicrobial agents between Acinetobacter baumannii and Acinetobacter genomic species 13TU.
- Authors
Jung Hoon Lee; Chul Hee Choi; Hee Young Kang; Ji Young Lee; Jungmin Kim; Yoo Chul Lee; Sung Yong Seol; Dong Taek Cho; Kun Woo Kim; Do Young Song; Je Chul Lee
- Abstract
<sec><st>Objectives</st> To investigate the differences in antimicrobial susceptibility and resistance mechanisms against imipenem between <it>Acinetobacter baumannii</it> and <it>Acinetobacter</it> genomic species 13TU. </sec> <sec><st>Methods</st> A total of 232 non-duplicate <it>Acinetobacter</it> species were consecutively collected from two Korean hospitals in Daegu, Republic of Korea, between November 2004 and November 2005. Antimicrobial susceptibility was determined by agar dilution methods. Resistance to imipenem was characterized by a carbapenemase activity test and PCR amplification. PFGE was performed to determine the clonal relatedness of imipenem-resistant <it>Acinetobacter</it> species. </sec> <sec><st>Results</st> <it>A. baumannii</it> was the most prevalent species (61.2%), followed by <it>Acinetobacter</it> genomic species 13TU (25.9%). The resistance rates of <it>A. baumannii</it> to most antimicrobial agents were higher than those of other <it>Acinetobacter</it> species, while the resistance rate to imipenem was the highest in <it>Acinetobacter</it> genomic species 13TU. Imipenem-resistant <it>Acinetobacter</it> genomic species 13TU isolates produced VIM-2 metallo-β-lactamase, while imipenem-resistant <it>A. baumannii</it> isolates produced OXA-23 and/or OXA-51 β-lactamase. Imipenem-resistant <it>Acinetobacter</it> strains originated from different clones in each hospital. </sec> <sec><st>Conclusions</st> Two prevalent <it>Acinetobacter</it> species, <it>A. baumannii</it> and <it>Acinetobacter</it> genomic species 13TU, possess distinct phenotypic and genotypic traits against antimicrobials. </sec>
- Subjects
NEISSERIACEAE; ACINETOBACTER; GENETICS; ANTI-infective agents
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2007, Vol 59, Issue 4, p633
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkm007