We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Immunosuppressant Drugs Mitigate Immune Responses Generated by Human Mesenchymal Stem Cells Transplanted into the Mouse Parenchyma.
- Authors
Hwang, Jung Won; Myeong, Su Hyeon; Lee, Na-Hee; Kim, Hyeongseop; Son, Hyo Jin; Chang, Jong Wook; Lee, Na Kyung; Na, Duk L.
- Abstract
It has been widely accepted that mesenchymal stem cells (MSCs) can evade the immune surveillance of the recipient. However, emerging research cast doubt on whether MSCs are intrinsically immune-privileged. Previously, we observed that the transplantation of human MSCs (hMSCs) into the mouse parenchyma attracted a high infiltration of leukocytes into the injection tract. Thus, in order to reduce the immune responses generated by hMSCs, the aim of this study was to assess which immunosuppressant condition (dexamethasone only, tacrolimus only, or dexamethasone and tacrolimus together) would not only reduce the overall immune response but also enhance the persistence of MSCs engrafted into the caudate putamen of wild-type C57BL/6 mice. According to immunohistochemical analysis, compared to the hMSC only group, the administration of immunosuppressants (for all three conditions) reduced the infiltration of CD45-positive leukocytes and neutrophils at the site of injection. The highest hMSC persistence was detected from the group that received combinatorial administrations of dexamethasone and tacrolimus. Moreover, compared to the immunocompetent WT mouse, higher MSC engraftment was observed from the immunodeficient BALB/c mice. The results of this study support the use of immunosuppressants to tackle MSC-mediated immune responses and to possibly prolong the engraftment of transplanted MSCs.
- Subjects
IMMUNOSUPPRESSIVE agents; MESENCHYMAL stem cells; LEUCOCYTES; CELL transplantation; IMMUNE response
- Publication
Cell Transplantation, 2021, Vol 30, p1
- ISSN
0963-6897
- Publication type
Article
- DOI
10.1177/09636897211019025