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- Title
Blood-borne angiogenic factors and sustained multiple implantation: a comparison of singleton and twin pregnancies.
- Authors
Groeneveld, Els; Lambers, Marieke J.; Hoozemans, Diederik A.; Schats, Roel; Hompes, Peter G. A.; Lambalk, Cornelis B.
- Abstract
This study aimed to compare longitudinal serum concentrations of angiogenic implantation factors between ongoing singleton and twin pregnancies after double-embryo transfer and to investigate whether these are involved in sustained double implantation. Sixteen patients with an ongoing singleton and nine patients with an ongoing twin pregnancy after double-embryo transfer were included in this prospective observational study. Main outcome measures were concentrations of vascular endothelial growth factor-A (VEGF-A), inhibin A, glycodelin A, insulin-like growth factor-I (IGF-I), insulin-like growth factor-II (IGF-II), insulin--like growth factor binding protein-1 (IGFBP-1) and insulin-like growth factor binding protein-3 (IGFBP-3) at baseline, during the IVF treatment and in early pregnancy. It appeared that VEGF-A concentrations prior to any treatment and at early implantation as welt as body mass index (BMI) were higher in women who conceived a twin pregnancy (P = 0.04). Soon after implantation, inhibin A concentrations were higher in twin pregnancies (P = 0.02). Secretion profiles of glycodelin A and members of the IGF family did not differ between singleton and twin pregnancies. VEGF-A appears to play a rote in sustained double implantation. Furthermore a high BMI is associated with ongoing double implantation. Future studies should investigate the predictive value of VEGF-A for having an ongoing singleton or twin pregnancy.
- Subjects
FERTILIZATION in vitro; NEOVASCULARIZATION; EMBRYO transfer; PREGNANCY; VASCULAR endothelial growth factors; SOMATOMEDIN; INSULIN-like growth factor-binding proteins
- Publication
Reproductive BioMedicine Online (Reproductive Healthcare Limited), 2010, Vol 20, Issue 6, p822
- ISSN
1472-6483
- Publication type
Article
- DOI
10.1016/j.rbmo.2010.02.019