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- Title
A Retrospective Genomic Landscape of 661 Young Adult Glioblastomas Diagnosed Using 2016 WHO Guidelines for Central Nervous System Tumors.
- Authors
Haberberger, James F; Pegram, Worthy; Britt, Nicholas; Schiavone, Kelsie; Severson, Eric; Sharaf, Radwa; Albacker, Lee A; Williams, Erik; Lechpammer, Mirna; Hemmerich, Amanda; Lin, Douglas; Huang, Richard S P; Hiemenz, Matthew; Elvin, Julia; Graf, Ryon; Lesser, Glenn; Kram, David; Strowd, Roy; Bi, Wenya Linda; Ramkissoon, Lori A
- Abstract
The authors present a cohort of 661 young adult glioblastomas diagnosed using 2016 WHO World Health Organization Classification of Tumors of the Central Nervous System , utilizing comprehensive genomic profiling (CGP) to explore their genomic landscape and assess their relationship to currently defined disease entities. This analysis explored variants with evidence of pathogenic function, common copy number variants (CNVs), and several novel fusion events not described in literature. Tumor mutational burden (TMB) mutational signatures, anatomic location, and tumor recurrence are further explored. Using data collected from CGP, unsupervised machine-learning techniques were leveraged to identify 10 genomic classes in previously assigned young adult glioblastomas. The authors relate these molecular classes to current World Health Organization guidelines and reference current literature to give therapeutic and prognostic descriptions where possible.
- Subjects
WORLD Health Organization; GENETIC mutation; SEQUENCE analysis; CENTRAL nervous system tumors; GLIOMAS; RETROSPECTIVE studies; MACHINE learning; CANCER relapse; GENOMICS; GENE expression profiling; GENOTYPES; LONGITUDINAL method; ADULTS
- Publication
Oncologist, 2024, Vol 29, Issue 1, pe47
- ISSN
1083-7159
- Publication type
Article
- DOI
10.1093/oncolo/oyad224