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- Title
A combination of anti- PD-L1 mAb plus Lm- LLO-E6 vaccine efficiently suppresses tumor growth and metastasis in HPV-infected cancers.
- Authors
Lin, Po‐Lin; Cheng, Ya‐Min; Wu, De‐Wei; Huang, Yu‐Ju; Lin, Hun‐Chi; Chen, Chih‐Yi; Lee, Huei
- Abstract
PD-1/ PD-L1 immunotherapy is viewed as having clinical benefits in advanced cancers but is effective in only a few patients, suggesting that an efficient combination approach is needed to improve efficacy. Immunohistochemistry analysis indicated that PD-L1 expression was correlated with the E6 expression in tumors from 122 lung cancer patients. The poorest survival occurred in PD-L1-positive/E6-positive tumor. PD-L1 expression was increased by the expression of E6, but not the E7, oncoprotein in lung and cervical cancer cells. PD-L1 expression was responsible for E6-mediated colony formation and soft agar growth. Therefore, PD-L1 secreted from tumor cells may directly promote tumor progression, particularly in E6-positive tumors. Immune deficiency nude mice were used to test the possibility that combining anti- PD-L1 mAb with Lm- LLO-E6 vaccine could have a higher antitumor activity compared with anti- PD-L1 mAb or Lm- LLO-E6 vaccine alone. A greater antitumor activity was obtained with anti- PD-L1 mAb + Lm- LLO-E6 vaccine than with anti- PD-L1 mAb or Lm- LLO-E6 alone in subcutaneous and metastatic tumors induced by TL-1 and SiHa cells. The longest survival time for nude mice was observed in the anti- PD-L1 mAb + Lm- LLO-E6 vaccine group. In conclusion, an anti- PD-L1 mAb + Lm- LLO-E6 vaccine may be an efficient treatment for suppression of tumor growth and metastasis induced by HPV-infected cells.
- Subjects
PROGRAMMED cell death 1 receptors; TUMOR growth; COMBINATION drug therapy; HUMAN papillomavirus vaccines; IMMUNOHISTOCHEMISTRY; GENE expression; GENETICS; PAPILLOMAVIRUS diseases; THERAPEUTICS
- Publication
Cancer Medicine, 2017, Vol 6, Issue 9, p2052
- ISSN
2045-7634
- Publication type
Article
- DOI
10.1002/cam4.1143