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- Title
Risk of Environmental Exposure to H7N9 Influenza Virus via Airborne and Surface Routes in a Live Poultry Market in Hebei, China.
- Authors
Zhang, Cheng; Guo, Kangkang; Cui, Huan; Chen, Ligong; Zhang, Chunmao; Wang, Xuejing; Li, Jiaming; Fu, Yingying; Wang, Zhongyi; Guo, Zhendong; Liu, Juxiang; Dong, Shishan
- Abstract
Environmental transmission of viruses to humans has become an early warning for potential epidemic outbreaks, such as SARS-CoV-2 and influenza virus outbreaks. Recently, an H7N9 virus, A/environment/Hebei/621/2019 (H7N9), was isolated by environmental swabs from a live poultry market in Hebei, China. We found that this isolate could be transmitted by direct contact and aerosol in mammals. More importantly, after 5 passages in mice, the virus acquired two adaptive mutations, PB1-H115Q and B2-E627K, exhibiting increased virulence and aerosol transmissibility. These results suggest that this H7N9 virus might potentially be transmitted between humans through environmental or airborne routes.
- Subjects
HEBEI Sheng (China); INFLUENZA A virus, H7N9 subtype; ENVIRONMENTAL risk; ENVIRONMENTAL exposure; RISK exposure; H7N9 Influenza; SARS-CoV-2; AVIAN influenza A virus
- Publication
Frontiers in Cellular & Infection Microbiology, 2021, Vol 11, p1
- ISSN
2235-2988
- Publication type
Article
- DOI
10.3389/fcimb.2021.688007