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- Title
Pediatric allo-SCT for malignant and non-malignant diseases: impact on health-related quality of life outcomes.
- Authors
Oberg, J A; Bender, J G; Morris, E; Harrison, L; Basch, C E; Garvin, J H; Sands, S A; Cairo, M S
- Abstract
The objective of this study was prospectively to investigate the health-related quality of life (HRQOL) of 80 pediatric recipients of allo-SCT for malignant and non-malignant diseases. The PedsQL 4.0 was used to assess self-reported physical, emotional and social functioning of children 5 years old once, pre-allo-SCT and on days +100, +180, +365 and +730. Emotional and social functioning was stable pre-to-post-allo-SCT and comparable to the normative sample (P>0.05), and physical functioning was 17 points lower pre-allo-SCT (P0.01) with improved scores equivalent to the norms by day +730. Lower physical scores were reflected by 50-54% of children reporting difficulties with movement, strength, pain and fatigue. At baseline, children ages 5-7 reported lower social functioning (P<0.05) and patients with non-malignant disease reported better physical functioning (P<0.05). Emotional functioning in ages 8-12 improved over time (P<0.05). More than 50% of the participants were minority and their HRQOL was similar to non-minority participants. Physical functioning significantly improved for recipients of reduced-toxicity conditioning (P0.01), significantly worsened for patients with chronic GVHD (cGVHD; P<0.05), and significantly decreased in recipients of matched-unrelated donor transplant who developed cGVHD (P<0.05). Multidisciplinary efforts are necessary to identify and support pediatric patients' physical needs to improve functional outcomes.
- Subjects
DRUG therapy; CHILDHOOD cancer; TUMORS in children; JUVENILE diseases; PEDIATRICS; QUALITY of life; PATIENTS; PHYSICAL therapy
- Publication
Bone Marrow Transplantation, 2013, Vol 48, Issue 6, p787
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/bmt.2012.217