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- Title
Left ventricular filling abnormalities and obesity-associated hypertension: relationship with overproduction of circulating transforming growth factor β1.
- Authors
Parrinello, G.; Licata, A.; Colomba, D.; Di Chiara, T.; Argano, C.; Bologna, P.; Corrao, S.; Avellone, G; Scaglione, R.; Licata, G.
- Abstract
This study has been designed to evaluate the relationship among transforming growth factor β1 (TGFβ1) and some measurements of diastolic function in a population of hypertensive subjects with normal left ventricular ejection fraction. We studied 67 hypertensive outpatients who according to their BMI levels were subdivided into three groups: lean (L), overweight (OW) and obese (OB) hypertensives (HT). Circulating TGFβ1 and M- and B-mode echocardiography was determined. All hypertensives were further subgrouped, according to European Society of Cardiology Guidelines, into two subsets of patients with normal diastolic function or with diastolic dysfunction. Prevalence of left ventricular hypertrophy (LVH) was determined in all the groups. TGFβ1, left ventricular mass (LVM), LVM/h2.7, E-wave deceleration time and isovolumic relaxation time (IVRT) were significantly (P<0.005) higher and E/A velocity ratio was significantly (P<0.05) lower in OW-HT and OB-HT than in L-HT. Prevalence of LVH was significantly higher (P<0.03) in group OB-HT than in L-HT. TGFβ1 (P<0.004), LVM/h2.7 (P<0.001) and prevalence of LVH were (P<0.01) significantly higher in hypertensives with diastolic dysfunction than hypertensives with normal diastolic function. TGFβ1 levels were positively correlated with BMI (r=0.60; P<0.0001), LVM/h2.7 (r=0.28; P<0.03), IVRT (r=0.30; P<0.02) and negatively with E/A ratio (r=−0.38; P<0.002) in all HT. Multiple regression analysis indicated that TGFβ1, BMI and IVRT were independently related to E/A ratio explaining 71% of its variability (r=0.84; P<0.0001). This relationship was independent of LVH, age and HR suggesting that TGFβ1 overproduction may be considered a pathophysiological mechanism in the development of left ventricular filling abnormalities in obesity-associated hypertension.Journal of Human Hypertension (2005) 19, 543–550. doi:10.1038/sj.jhh.1001864 Published online 21 April 2005
- Subjects
LEFT heart ventricle; HYPERTENSION; OBESITY; TRANSFORMING growth factors; INTERNAL medicine; CLINICAL epidemiology; MEDICAL research
- Publication
Journal of Human Hypertension, 2005, Vol 19, Issue 7, p543
- ISSN
0950-9240
- Publication type
Article
- DOI
10.1038/sj.jhh.1001864