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- Title
Anti-Fatigue Effects of Enzyme-Modified Ginseng Extract: A Randomized, Double-Blind, Placebo-Controlled Trial.
- Authors
Lee, Namhun; Lee, Suk-Hoon; Yoo, Ho-Ryong; Yoo, Hwa Seung
- Abstract
Objectives: Ginseng saponin is known to have biological activities in maintaining homeostasis and enhancing vital energy. Enzyme-modified ginseng extract (EMGE) was designed to increase the content of its active constituents and to intensify biological activity. The present study investigated the anti-fatigue effects of EMGE in healthy adults in a randomized, double-blind, placebo-controlled trial. Design: Fifty-two healthy subjects met the diagnostic criteria and were randomly allocated into one of two groups: EMGE (2,000 mg/day) or placebo. EMGE or placebo were administered to each group for 4 weeks. Fatigue scores using the Visual Analogue Fatigue Scale (VAFS) and Revised Piper Fatigue Scale (RPFS) were considered as the primary outcome measure. Life-quality scores were investigated using the Short-Form Health Survey (SF-36). The safety and adverse effects of EMGE were also assessed. Results: A repeated-measures analysis of variance showed that there was a significant difference in the VAFS scores VAFS between the treatment and placebo groups after 4 weeks. The treatment group's score decreased more than that of the placebo group. There was no difference in the RPFS and SF-36 scores between the two groups. There were no fatal adverse effects. Conclusion: EMGE treatment for 4 weeks decreased fatigue severity in a healthy population. Adverse effects were rare, and EMGE was generally well tolerated. Randomized, placebo-controlled trials of EMGE are justified in order to elucidate the underlying mechanism of EMGE in combating fatigue.
- Subjects
SOUTH Korea; ANALYSIS of variance; ASPARTATE aminotransferase; CREATININE; FATIGUE (Physiology); GINGER; GINSENG; HEALTH surveys; PLACEBOS; PROBABILITY theory; QUALITY of life; QUESTIONNAIRES; RESEARCH funding; PLANT extracts; SAMPLE size (Statistics); STATISTICAL power analysis; EFFECT sizes (Statistics); ALANINE aminotransferase; RANDOMIZED controlled trials; TREATMENT effectiveness; REPEATED measures design; BLIND experiment; DATA analysis software; DESCRIPTIVE statistics; BLOOD urea nitrogen
- Publication
Journal of Alternative & Complementary Medicine, 2016, Vol 22, Issue 11, p859
- ISSN
1075-5535
- Publication type
Article
- DOI
10.1089/acm.2016.0057