We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK-cell subset distribution in children.
- Authors
Noyola, Daniel E.; Fortuny, Claudia; Muntasell, Aura; Noguera-Julian, Antoni; Muñoz-Almagro, Carmen; Alarcón, Ana; Juncosa, Teresa; Moraru, Manuela; Vilches, Carlos; López-Botet, Miguel
- Abstract
Human cytomegalovirus (HCMV) has been reported to reshape the NK-cell receptor (NKR) distribution, promoting an expansion of CD94/NKG2C+ NK and T cells. The role of NK cells in congenital HCMV infection is ill-defined. Here we studied the expression of NKR (i.e., NKG2C, NKG2A, LILRB1, CD161) and the frequency of the NKG2C gene deletion in children with past congenital infection, both symptomatic ( n = 15) and asymptomatic ( n = 11), including as controls children with postnatal infection ( n = 11) and noninfected ( n = 20). The expansion of NKG2C+ NK cells in HCMV-infected individuals appeared particularly marked and was associated with an increased number of LILRB1+ NK cells in cases with symptomatic congenital infection. Increased numbers of NKG2C+, NKG2A+, and CD161+ T cells were also associated to HCMV infection. The NKG2C deletion frequency was comparable in children with congenital HCMV infection and controls. Remarkably, the homozygous NKG2C+/+ genotype appeared associated with increased absolute numbers of NKG2C+ NK cells. Moreover, HCMV-infected NKG2C+/+ children displayed higher absolute numbers of NKG2A+ and total NK cells than NKG2C+/− individuals. Our study provides novel insights on the impact of HCMV infection on the homeostasis of the NK-cell compartment in children, revealing a modulatory influence of NKG2C copy number.
- Publication
European Journal of Immunology, 2012, Vol 42, Issue 12, p3256
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.201242752