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- Title
Phenylpropanoids from red kohlrabi sprouts inhibits nitric oxide production in RAW 264.7 macrophage cells.
- Authors
Lee, Jae-Woong; Lee, Dae-Young; Baek, Dong-Ryeol; Jeong, Rak-Hoon; Lee, Dong-Sung; Kim, Youn-Chul; Kim, Geum-Soog; Baek, Nam-In; Lee, Youn-Hyung
- Abstract
The sprouts of red kohlrabi ( Brassica oleracea var. gongylodes) were extracted with methanol, and the concentrated extracts were successively partitioned with ethyl acetate, n-butyl alcohol ( n-BuOH), and HO. From the n-BuOH fraction, four phenylpropanoids were isolated through repeated silica gel and ODS column chromatographies. On the basis of physico-chemical and spectroscopic data including NMR, MS, and IR, the isolated compounds were identified as 3-(3,4,5-trimethoxyphenyl)-2 E-propenoic acid methyl ester ( 1), ( E)-sinapic acid methyl ester ( 2), ( E)-sinapoyl glucoside ( 3), and lawsoniaside B ( 4). Moreover, the compounds dose-dependently inhibited NO production in RAW 264.7 cells with IC values of 41.22 ( 1), 38.32 ( 3), and 22.65 ( 4) μM, respectively. With further studies, these compounds may be potentially useful in developing new anti-inflammatory agents.
- Publication
Food Science & Biotechnology, 2014, Vol 23, Issue 3, p965
- ISSN
1226-7708
- Publication type
Article
- DOI
10.1007/s10068-014-0130-4