We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
INVASIVE PNEUMOCOCCAL DISEASE IN HIGH RISK PATIENTS.
- Authors
Luminos, Monica; Draganescu, Anca; Vasile, Magda; Visan, Angelica; Negulescu, Cristina; Dogaru, Cornelia; Slavu, Diana; Bilasco, Anuta
- Abstract
Introduction. The clinical and epidemiological burden of Invasive Pneumococcal Disease (IPD) is still very increased. In the pathogenesis of Invasive Pneumococcal Disease there are three essential elements involved: nasopharyngeal colonization, the inflammatory response of the host and also the effect of viral and bacterial co-infections on pneumococcus virulence. The highest susceptibility for IPD is found in children less than 5 years of age, especially in those under 2 years of age. Concerning the risk factors for IPD, the most important are congenital malformations or trauma of the skull with rhinoliquorrhea and otoliquorrhea, along with immunodeficiency and other chronic conditions. Material and method: This paper highlights skull malformations with corticospinal fluid (CSF) fistula as a risk factor in developing IPD, like sepsis or recurrent bacterial meningitis. During 2014-2015 in our clinic there have been 3 cases of sepsis with meningitis with Streptococcus pneumoniae in children with CSF fistula. We report the case of a 4-year-old patient with sepsis and recurrent meningitis with Streptococcus pneumoniae serotype 6B, resistant to Penicillin, with repeated surgical interventions for naso-frontal CSF fistula with rhinoliquorrhea. Conclusions: The diagnosis and treatment of these affections need considerable effort from a multidisciplinary medical team with the ultimate goal of making a quick recovery of the patient and avoidance of recurrence. During 2010-2013, ACIP (Advisory Committee on Immunization Practices) published new recommendations for vaccination with PCV13 and PPSV 23 regarding patients with high risk factors for IPD, highlighting the ongoing clinical burden of this affection.
- Subjects
STREPTOCOCCUS pneumoniae; EPIDEMIOLOGY; PNEUMOCOCCAL vaccines; NASOPHARYNGITIS; IMMUNODEFICIENCY
- Publication
Jurnalul Pediatrului, 2015, Vol 18, p133
- ISSN
2360-4557
- Publication type
Article