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- Title
Photodecarboxylative Benzylations of N-Methoxyphthalimide under Batch and Continuous-Flow Conditions.
- Authors
Wang, Jun; Junk, Peter C.; Oelgemöller, Michael; Pordanjani, Hossein Mohammadkhani; Faderl, Christian; Motti, Cherie A.
- Abstract
A series of photodecarboxylative benzylations of N- methoxyphthalimide were successfully realised using easily accessible starting materials. The reactions proceeded smoothly and the corresponding benzylated hydroxyphthalimidines were obtained in moderate to good yields of 52–73 %. No competing photoinduced dealkoxylation of the N- methoxy group was observed. The reaction with potassium phenylacetate was subsequently investigated in an advanced continuous-flow photoreactor. The reactor allowed rapid optimization of the reaction conditions and gave the desired benzylated product in higher yield and shorter irradiation time compared with the batch process.
- Subjects
PHOTOCHEMICAL research; METHOXY group; CONTINUOUS flow reactors
- Publication
Australian Journal of Chemistry, 2015, Vol 68, Issue 11, p1662
- ISSN
0004-9425
- Publication type
Article
- DOI
10.1071/CH15356