We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Design and Synthesis of Two Methylthiosteroid-Oxirenol Derivatives: Theoretical Evaluation of Their Interaction with B1-Cannabinoid Receptor.
- Authors
Lauro, Figueroa-Valverde; Francisco, Diaz-Cedillo; Marcela, Rosas-Nexticapa; Alejandra, Garcimarero-Espino E.; Virginia, Mateu-Armand; Maria, Lopez-Ramos; Hau-Heredia-Lenin; Raquel, Estrella-Barron; Yaritza, Borges-Ballote
- Abstract
Several agonists and antagonists of B1 cannabinoid receptors have been synthesized for the treatment of several clinical pathologies such as psychosis, hyperalgesia, and drug addiction; however, some of these drugs may produce some side effects including higher intraocular pressure, hepatotoxicity, etc. The aim of this study was to synthesize two new methylthiosteroidoxirenol derivatives (compounds 7 and 8) to evaluate their theoretical interaction with B1 cannabinoid receptor (5gtz) using WIN-55,212-2, yangonin, cannabigerol, and tetrahydrocannabivarin drugs as controls in a docking model. The preparation of 7 and 8 were carried out using a series of reactions which involved nitration, etherification, hydrogenationchlorination, and addition. The chemical structure of the compounds was confirmed using elemental analysis and NMR spectrum. The results showed that compound 7 or 8 could bind to different types of amino acid residues involved in 5gtz protein surface compared with the WIN 55,212-2, Yangonin, Cannabigerol, and Tetrahydrocannabivarin drugs. All data suggest that compound 7 or 8 may exert changes in the biological activity of B1 cannabinoid receptor.
- Subjects
STEROID synthesis; CANNABINOID receptors; HYPERALGESIA treatment; TREATMENT of drug addiction; NITRATION; ETHERIFICATION
- Publication
Journal of Biochemical Technology, 2019, Vol 10, Issue 4, p29
- ISSN
0974-2328
- Publication type
Article