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- Title
Platelet and granulocyte alloimmunisation in multitransfused Tunisian patients.
- Authors
Skouri, Hadef; Bettaieb, Ali; Fromont, Patricia; Elomri, Halima; Ennabli, Souad; Bierling, Philippe
- Abstract
Skouri H, Bettaieb A, Fromont P, Elomri H, Ennabli S, Bierling P. Platelet and granulocyte alloimmunisation in multitransfused Tunisian patients. Eur J Haematol 2005: 75: 248–251. © Blackwell Munksgaard 2005. We determined the frequency of post-transfusion alloimmunisation against platelet and granulocyte antigens in 51 Tunisian polytransfused patients with haematological diseases. Serum samples were analysed by a standard and an antiglobulin-augmented lymphocytotoxicity technique, a granulocyte agglutination test, a granulocyte immunofluorescence test, a platelet immunofluorescence test and the monoclonal antibody-specific immobilisation of platelet antigens assay. No granulocyte-specific antibodies were detected. HLA antibodies were found in 58.8% of patients. Platelet-specific antibodies were detected in four patients and were directed against human platelet antigen (HPA)-5b, HPA-1b and HPA-3a. The three patients with Glanzmann's thrombasthenia developed anti-GPIIb/IIIa antibodies. This study provides immunogenetic information that could improve the management of transfusion therapy in Tunisia.
- Subjects
BLOOD platelets; GRANULOCYTES; BLOOD diseases; AGGLUTINATION tests; IMMUNOGLOBULINS; HLA histocompatibility antigens; BLOOD transfusion
- Publication
European Journal of Haematology, 2005, Vol 75, Issue 3, p248
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/j.1600-0609.2005.00494.x