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- Title
Metabolite Profiling Uncovers Plasmid-Induced Cobalt Limitation under Methylotrophic Growth Conditions.
- Abstract
The article discusses a study that presents evidence for a carbon flux diversion from the glycolytic pathway to the pentose phosphate pathway as a consequence of plasmid maintenance. It has been informed that the study found that antibiotic resistance proteins encoded on many plasmids may responsible for decreased growth rates by disturbing cellular functions. It has been informed that Serratia marcescens lactamase blaSME-1 is an example of toxic effects of an antibiotic resistance protein, whose signal sequence may be involved in growth rate reduction of E. coli strains heterologously expressing this protein.
- Subjects
PENTOSE phosphate pathway; HEXOSE phosphate metabolism; PHYSIOLOGICAL oxidation; PLASMIDS; ANTIBIOTICS; ESCHERICHIA coli
- Publication
PLoS ONE, 2009, Vol 4, Issue 11, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0007831