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- Title
THE ROLE OF LIPIDS IN DRUG ABSORPTION THROUGH THE GIT.
- Authors
Doktorovova, Slavomira; Morsy, Tarek; Balcão, Victor M.; Souto, Eliana B.
- Abstract
Lipid carriers show several advantages for oral delivery of pharmacologically active drugs, e.g. are composed of lipid molecules similar to those in human tissues, becoming therefore biocompatible, biotolerable and biodegradable. Examples include traditional o/vv emulsions, suspensions of lipid nanoparticles (SLNs and NLCs) and, recently, the SolEmuls®, which allows localizing poorly soluble drug molecules both in oil and agueous phases, in the interfacial layer of lecithin. This paper reports on the role of lipids in enhancing both drug absorption and bioavailability when administered orally.
- Subjects
LIPIDS; DRUG absorption; MOLECULES; TISSUES; BIOCOMPATIBILITY; BIODEGRADATION; BIOAVAILABILITY
- Publication
Revista da Faculdade de Ciências da Saúde, 2008, Vol 5, p192
- ISSN
1646-0480
- Publication type
Article