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- Title
Neural Stem Cells and Glioblastoma.
- Authors
RISPOLI, ROSSELLA; CONTI, CARLO; CELLI, PAOLO; CAROLI, EMANUELA; CARLETTI, SANDRO
- Abstract
Glioblastoma multiforme represents one of the most common brain cancers with a rather heterogeneous cellular composition, as indicated by the term “multiforme”. Recent reports have described the isolation and identification of cancer neural stem cells from human adult glioblastoma multiforme, which possess the capacity to establish, sustain, and expand these tumours, even under the challenging settings posed by serial transplantation experiments. Our study focused on the distribution of neural cancer stem cells inside the tumour. The study is divided into three phases: removal of tumoral specimens in different areas of the tumour (centre, periphery, marginal zone) in an operative room equipped with a 1.5 T scanner; isolation and characterization of neural cancer stem cells from human adult glioblastoma multiforme; identification of neural cancer stem cell distribution inside the tumour.
- Subjects
GLIOMA treatment; GLIOMAS; IMMUNOHISTOCHEMISTRY; MAGNETIC resonance imaging; HEALTH outcome assessment; STEM cells; TREATMENT effectiveness; DIAGNOSIS
- Publication
Neuroradiology Journal, 2014, Vol 27, Issue 2, p167
- ISSN
1971-4009
- Publication type
Article
- DOI
10.15274/NRJ-2014-10028